Patterns of Sequelae in Women with a History of Localized Breast Cancer: Results from the French VICAN Survey

Lidia Delrieu (1, 2, 3) , Liacine Bouaoun (4) , Douae El Fatouhi (5, 6) , Elise Dumas (2, 3, 7, 8) , Anne-Déborah Bouhnik (9) , Hugo Noelle (1) , Emmanuelle Jacquet (10, 11) , Anne-Sophie Hamy (2, 3) , Florence Coussy (2, 3) , Fabien Reyal (2, 3) , Pierre-Etienne Heudel (1) , Marc-Karim Bendiane (9) , Baptiste Fournier (1) , Mauricette Michallet (1) , Béatrice Fervers (1, 12) , Guy Fagherazzi (5, 6, 13) , Olivia Pérol (1, 12)

1 Centre Léon Bérard [Lyon]
2 RT2Lab - Residual Tumor & Response to Treatment Laboratory [Paris]
3 U932 - Immunité et cancer
4 CIRC - Centre international de Recherche sur le Cancer
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 IGR - Institut Gustave Roussy
7 Mines Paris - PSL (École nationale supérieure des mines de Paris)
8 CBIO - Centre de Bioinformatique
9 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
10 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
11 UGA - Université Grenoble Alpes
12 Inserm U1296 - Unité Ad Hoc INSERM 000008 "Radiations : Défense, Santé, Environnement" [Lyon]
13 LIH - Luxembourg Institute of Health

Breast cancer (BC) remains complex for women both physically and psychologically. The objectives of this study were to (1) assess the evolution of the main sequelae and treatment two and five years after diagnosis in women with early-stage breast cancer, (2) explore patterns of sequelae associated with given sociodemographic, clinical, and lifestyle factors. The current analysis was based on 654 localized BC patients enrolled in the French nationwide longitudinal survey "vie après cancer" VICAN (January-June 2010). Information about study participants was collected at enrollment, two and five years after diagnosis. Changes over time of the main sequelae were analyzed and latent class analysis was performed to identify patterns of sequelae related to BC five years after diagnosis. The mean age (±SD) of study participants at inclusion was 49.7 (±10.5) years old. Six main classes of sequelae were identified two years and five years post-diagnosis (functional, pain, esthetic, fatigue, psychological, and gynecological). A significant decrease was observed for fatigue (p = 0.03) and an increase in cognitive sequelae was reported (p = 0.03). Two latent classes were identified-functional and esthetic patterns. Substantial sequelae remain up to five years after BC diagnosis. Changes in patient care pathways are needed to identify BC patients at a high risk.

Mots clés: VICAN; breast cancer; prevention; sequelae

Domaines: Sciences du Vivant [q-bio]

Lidia Delrieu, Liacine Bouaoun, Douae El Fatouhi, Elise Dumas, Anne-Déborah Bouhnik, et al.. Patterns of Sequelae in Women with a History of Localized Breast Cancer: Results from the French VICAN Survey. Cancers, 2021, 13 (5), pp.1161. ⟨10.3390/cancers13051161⟩. ⟨inserm-03462253⟩