Skip to Main content Skip to Navigation
Journal articles

Novel thermo-responsive micelles prepared from amphiphilic hydroxypropyl methyl cellulose-block-JEFFAMINE copolymers

Abstract : A series of amphiphilic and thermo-responsive block copolymers were synthesized by reductive amination betweenthe aldehyde endgroup of hydrophilic HPMC and the amine group of monoamine, diamine, or triamineJEFFAMINE as hydrophobic block. The resulting diblock, triblock and three-armed copolymers with different hydrophilic/hydrophobic ratios and block lengths were characterized by NMR, FT-IR, DOSY-NMR and SEC. Thecloud point (CP) of copolymers was determined by UV–visible spectrometer. Data show that both the geometricalstructure and the molarmass of HPMC affect the CP of HPMC-JEF copolymers. The higher the hydrophilic/hydrophobicratio, the higher the CP of copolymers which is lower than that of HPMC homopolymers. The selfassemblybehavior of the copolymers was investigated from dynamic light scattering, transmission electronmicroscopy,and critical micelle concentration (CMC) measurements. Spherical nano-micelles are obtained by selfassemblyof copolymers in aqueous solution, and the micelle size can be tailored by varying the block length ofHPMC and the geometrical structure. Three-armed HPMC-JEF copolymers present lowerCMC and smallermicellesize as compared to linear diblock and triblock ones.MTT assay evidenced the cytocompatibility of HPMC-JEF copolymers,indicating that they could be promising as drug carrier in drug delivery systems.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-02141702
Contributor : Accord Elsevier Ccsd Connect in order to contact the contributor
Submitted on : Monday, October 25, 2021 - 9:31:30 AM
Last modification on : Wednesday, November 3, 2021 - 6:15:19 AM

File

S0141813019304362.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Collections

Citation

Aijing Lu, Eddy Petit, Suming Li, Yuandou Wang, Feng Su, et al.. Novel thermo-responsive micelles prepared from amphiphilic hydroxypropyl methyl cellulose-block-JEFFAMINE copolymers. International Journal of Biological Macromolecules, Elsevier, 2019, 135, pp.38-45. ⟨10.1016/j.ijbiomac.2019.05.087⟩. ⟨hal-02141702⟩

Share

Metrics

Record views

79

Files downloads

7