Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study - Ifsttar Accéder directement au contenu
Article Dans Une Revue PLoS Medicine Année : 2017

Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study

Résumé

BACKGROUND:While some medicinal drugs have been found to affect driving ability, no study has investigated whether a relationship exists between these medicines and crashes involving pedestrians. The aim of this study was to explore the association between the use of medicinal drugs and the risk of being involved in a road traffic crash as a pedestrian.METHODS AND FINDINGS:Data from 3 French nationwide databases were matched. We used the case-crossover design to control for time-invariant factors by using each case as its own control. To perform multivariable analysis and limit false-positive results, we implemented a bootstrap version of Lasso. To avoid the effect of unmeasured time-varying factors, we varied the length of the washout period from 30 to 119 days before the crash. The matching procedure led to the inclusion of 16,458 pedestrians involved in an injurious road traffic crash from 1 July 2005 to 31 December 2011. We found 48 medicine classes with a positive association with the risk of crash, with median odds ratios ranging from 1.12 to 2.98. Among these, benzodiazepines and benzodiazepine-related drugs, antihistamines, and anti-inflammatory and antirheumatic drugs were among the 10 medicines most consumed by the 16,458 pedestrians. Study limitations included slight overrepresentation of pedestrians injured in more severe crashes, lack of information about self-medication and the use of over-the-counter drugs, and lack of data on amount of walking.CONCLUSIONS:Therapeutic classes already identified as impacting the ability to drive, such as benzodiazepines and antihistamines, are also associated with an increased risk of pedestrians being involved in a road traffic crash. This study on pedestrians highlights the necessity of improving awareness of the effect of these medicines on this category of road user.
Fichier principal
Vignette du fichier
ff6068cb8f2cf34acf988ab3199f853b.pdf (1.77 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01577941 , version 1 (15-01-2024)

Licence

Paternité

Identifiants

Citer

Née Mélanie, Marta Fernandez Avalos, Audrey Luxcey, Benjamin Contrand, L Rachid Salmi, et al.. Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study. PLoS Medicine, 2017, pp.1-19. ⟨10.1371/journal.pmed.1002347⟩. ⟨hal-01577941⟩
251 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More