Inclusion complexes of γ-cyclodextrin and carboxyl-modified γ-cyclodextrin with C60: Synthesis, characterization and controlled release application via microgels

Adrian Fifere (1) , Tatiana Budtova (2) , Elena Tarabukina (2, 3) , Mariana Pinteala (1) , Spulber Mariana (1) , Cristian Peptu , Valeria Harabagiu (1) , Bogdan C. Simionescu (1)

1 “Petru Poni” Institute of Macromolecular Chemistry
2 CEMEF - Centre de Mise en Forme des Matériaux
3 Institute of Macromolecular Compounds

Carboxyl modified gamma-cyclodextrin (CDSA) with a substitution degree of about 9.5 was prepared by the esterification of gamma-cyclodextrin (CD) with succinic anhydride in pyridine at 90 A degrees C. The chemical composition and the structure of CDSA were characterized by FT-IR, MALDI-TOF, X-ray diffraction pattern, potentiometric titration and TGA. Modified and native gamma-cyclodextrin associate with fullerene (C-60) in DMF-toluene mixture resulting 1:1 CDSA:C-60 and CD:C-60 inclusion complexes. Aqueous solutions of native cyclodextrin, carboxyl-modified cyclodextrin and their inclusion complexes with C-60 were used as microgel solvent (or swelling agent) for controlled release application. The release of solutions was induced by shear stress and demonstrated using rheo-optical set-up.

Mots clés: Fullerene C-60; Inclusion complexes; Shear induced release from microgel; Carboxyester modified gamma-cyclodextrin

Domaines: Matériaux

Adrian Fifere, Tatiana Budtova, Elena Tarabukina, Mariana Pinteala, Spulber Mariana, et al.. Inclusion complexes of γ-cyclodextrin and carboxyl-modified γ-cyclodextrin with C60: Synthesis, characterization and controlled release application via microgels. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 64 (1-2), pp.Pages 83-94. ⟨10.1007/s10847-009-9539-4⟩. ⟨hal-00509203⟩