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Protein-functionalized hairy diamond nanoparticles

Abstract : Diazonium salt chemistry and atom transfer radical polymerization (ATRP) were combined in view of preparing new bioactive hairy diamond nanoparticles containing, or potentially containing, nitrogen-vacancy (NV) fluorescent centers (fluorescent nanodiamonds, or fNDs). fNDs were modified by ATRP initiators using the electroless reduction of the diazonium salt BF4−,+N2−C6H4−CH(CH3)−Br. The strongly bound aryl groups −C6H4−CH(CH3)−Br efficiently initiated the ATRP of tert-butyl methacrylate (tBMA) at the surface of the nanodiamonds, which resulted in obtaining ND-PtBMA hybrids. The grafted chain thickness, estimated from X-ray photoelectron spectroscopy (XPS), was found to increase linearly with respect to time before reaching a plateau value of ca. 2 nm. These nanoobjects were further hydrolyzed into ND-PMAA (where PMAA is the poly(methacrylic acid) graft) and further decorated by bovine serum albumin through the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling procedure.
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https://hal-mines-paristech.archives-ouvertes.fr/hal-00523275
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Submitted on : Monday, October 4, 2010 - 4:28:58 PM
Last modification on : Wednesday, October 14, 2020 - 4:07:03 AM

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Si Amar Dahoumane, Minh Ngoc Nguyen, Alain Thorel, Jean-Paul Boudou, Mohamed M Chehimi, et al.. Protein-functionalized hairy diamond nanoparticles. Langmuir, American Chemical Society, 2009, 25, pp.9633-9638. ⟨10.1021/la9009509⟩. ⟨hal-00523275⟩

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