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Article dans une revue

Shear-induced solvent release from gel particles: application to drug-delivery systems

Abstract : he behaviour of a swollen-in-water hydrogel particle and of a chitosan-alginate micro-capsule immersed in a silicon oil under shear is studied by the rheo-optical method. Both gel and capsule quantitatively behave in a same way. Shear stress leads to a solvent release from a particle and a further increase of shear stress induces the solvent detachment from the released areas. Particle deformation and solvent release are reversible: when stopping the shear, the particle recovers its initial shape and volume. But when some solvent is detached, it flows separately as would do low-viscosity droplets immersed in a high-viscosity matrix.
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https://hal-mines-paristech.archives-ouvertes.fr/hal-00574694
Contributeur : Magalie Prudon <>
Soumis le : mardi 8 mars 2011 - 15:58:57
Dernière modification le : jeudi 24 septembre 2020 - 17:22:55

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Anna Zanina, Alexander Vilesov, Tatiana Budtova. Shear-induced solvent release from gel particles: application to drug-delivery systems. International Journal of Pharmaceutics, Elsevier, 2002, 242 (1-2), pp.Pages 137-146. ⟨10.1016/S0378-5173(02)00185-0⟩. ⟨hal-00574694⟩

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