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Article Dans Une Revue International Journal of Pharmaceutics Année : 2002

Shear-induced solvent release from gel particles: application to drug-delivery systems

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Résumé

he behaviour of a swollen-in-water hydrogel particle and of a chitosan-alginate micro-capsule immersed in a silicon oil under shear is studied by the rheo-optical method. Both gel and capsule quantitatively behave in a same way. Shear stress leads to a solvent release from a particle and a further increase of shear stress induces the solvent detachment from the released areas. Particle deformation and solvent release are reversible: when stopping the shear, the particle recovers its initial shape and volume. But when some solvent is detached, it flows separately as would do low-viscosity droplets immersed in a high-viscosity matrix.

Dates et versions

hal-00574694 , version 1 (08-03-2011)

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Anna Zanina, Alexander Vilesov, Tatiana Budtova. Shear-induced solvent release from gel particles: application to drug-delivery systems. International Journal of Pharmaceutics, 2002, 242 (1-2), pp.Pages 137-146. ⟨10.1016/S0378-5173(02)00185-0⟩. ⟨hal-00574694⟩
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