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Intermittent simulated moving bed chromatography: 3. Separation of Tröger's base enantiomers under nonlinear conditions

Abstract : One of the modified simulated moving bed (SMB) processes, the intermittent SMB (I-SMB) process, has been recently analyzed theoretically [1] and its superior performance compared to the conventional SMB process has been demonstrated at a rather low total feed concentration through experiments and simulations [2]. This work shows that the I-SMB process outperforms the conventional SMB process also at high feed concentration where the species are clearly subject to a nonlinear adsorption isotherm. In the case of the separation of the Tröger's base's enantiomers in ethanol on ChiralPak AD, the two processes operated in a six-column 1-2-2-1 configuration (one column in sections 1 and 4 and two columns in sections 2 and 3) and in a four-column 1-1-1-1 configuration (one column in each section) are compared at high feed concentration through both experiments and simulations. Even under nonlinear conditions the four column I-SMB process can successfully separate the two enantiomers achieving purity levels as high as the two six column processes and exhibiting better productivity.
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Submitted on : Monday, January 16, 2012 - 3:34:45 PM
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Shigeharu Katsuo, Christian Langel, Anne-Laure Sandré, Marco Mazzotti. Intermittent simulated moving bed chromatography: 3. Separation of Tröger's base enantiomers under nonlinear conditions. Journal of Chromatography A, Elsevier, 2011, 1218 (52), pp.9345-9352. ⟨10.1016/j.chroma.2011.10.073⟩. ⟨hal-00660395⟩

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