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Journal articles
Intermittent simulated moving bed chromatography: 3. Separation of Tröger's base enantiomers under nonlinear conditions
Abstract : One of the modified simulated moving bed (SMB) processes, the intermittent SMB (I-SMB) process, has been recently analyzed theoretically [1] and its superior performance compared to the conventional SMB process has been demonstrated at a rather low total feed concentration through experiments and simulations [2]. This work shows that the I-SMB process outperforms the conventional SMB process also at high feed concentration where the species are clearly subject to a nonlinear adsorption isotherm. In the case of the separation of the Tröger's base's enantiomers in ethanol on ChiralPak AD, the two processes operated in a six-column 1-2-2-1 configuration (one column in sections 1 and 4 and two columns in sections 2 and 3) and in a four-column 1-1-1-1 configuration (one column in each section) are compared at high feed concentration through both experiments and simulations. Even under nonlinear conditions the four column I-SMB process can successfully separate the two enantiomers achieving purity levels as high as the two six column processes and exhibiting better productivity.
https://hal-mines-paristech.archives-ouvertes.fr/hal-00660395
Contributor : Bibliothèque Mines Paristech <>
Submitted on : Monday, January 16, 2012 - 3:34:45 PM
Last modification on : Friday, April 9, 2021 - 2:30:04 PM
Contributor : Bibliothèque Mines Paristech <>
Submitted on : Monday, January 16, 2012 - 3:34:45 PM
Last modification on : Friday, April 9, 2021 - 2:30:04 PM