3-(2,4-Dimethoxybenzylidene)-anabaseine: A promising candidate drug for Alzheimer's disease? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Geriatrics and Gerontology International Année : 2012

3-(2,4-Dimethoxybenzylidene)-anabaseine: A promising candidate drug for Alzheimer's disease?

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Résumé

3-(2,4-Dimethoxybenzylidene)-anabaseine is an analog of the paralytic alkaloid, anabaseine, from the ribbon worms Amphiporus sp., that shows numerous properties, in particular an agonist activity on alpha7 nicotinic acetylcholine receptors. This article reviews these properties and explains to what extent they could be valuable to control symptomatology and/or neurodegeneration in Alzheimer's disease.

Dates et versions

hal-00820992 , version 1 (07-05-2013)

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Citer

Philippe Zawieja, Jean-Michel Kornprobst, Patrick Métais. 3-(2,4-Dimethoxybenzylidene)-anabaseine: A promising candidate drug for Alzheimer's disease?. Geriatrics and Gerontology International, 2012, 12 (3), p. 365-371. ⟨10.1111/j.1447-0594.2011.00827.x⟩. ⟨hal-00820992⟩
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