3-(2,4-Dimethoxybenzylidene)-anabaseine: A promising candidate drug for Alzheimer's disease?

Philippe Zawieja (1, 2) , Jean-Michel Kornprobst (3) , Patrick Métais (4)

1 CRC - Centre de recherche sur les Risques et les Crises
2 Orpéa/Clinéa
3 Laboratory of Marine Chemistry
4 Health Luxembourg

3-(2,4-Dimethoxybenzylidene)-anabaseine is an analog of the paralytic alkaloid, anabaseine, from the ribbon worms Amphiporus sp., that shows numerous properties, in particular an agonist activity on alpha7 nicotinic acetylcholine receptors. This article reviews these properties and explains to what extent they could be valuable to control symptomatology and/or neurodegeneration in Alzheimer's disease.

Mots clés: acetylcholinesterase inhibitors; Alzheimer's disease; amyloid-β; anabaseine; neuroinflammation

Domaines: Gestion des risques et des crises; Psychiatrie et santé mentale

Philippe Zawieja, Jean-Michel Kornprobst, Patrick Métais. 3-(2,4-Dimethoxybenzylidene)-anabaseine: A promising candidate drug for Alzheimer's disease?. Geriatrics and Gerontology International, 2012, 12 (3), p. 365-371. ⟨10.1111/j.1447-0594.2011.00827.x⟩. ⟨hal-00820992⟩