Novel Mechanisms for Augmenting Diabetic Wound Healing

D. Knobel (1) , J.L. Crawford (1) , P. D. Nguyen (1) , J. Tutela (1) , V.D. Thanik (1) , Jean-Claude Klein (1, 2) , O. Eydlin (1) , O. Cohen (1) , E.H. Davidson (1) , J.P. Levine (1)

1 NYU Institute of Reconstructive Plastic Surgery
2 CMM - Centre de Morphologie Mathématique

Impaired diabetic wound healing is multi-factorial and incompletely understood. Reactive oxygen species (ROS) and p53, a master gene regulator, are upregulated in diabetic wounds. We have demonstrated improved diabetic wound healing through a novel topical p53 silencing system. We hypothesized that topical silencing of p53 improves diabetic wound healing through a decrease in ROS.

Domaines: Ingénierie biomédicale

D. Knobel, J.L. Crawford, P. D. Nguyen, J. Tutela, V.D. Thanik, et al.. Novel Mechanisms for Augmenting Diabetic Wound Healing. Journal of Surgical Research, 2010, 158 (2), pp.322. ⟨10.1016/j.jss.2009.11.416⟩. ⟨hal-00836604⟩