Association of UV radiation with Parkinson's disease incidence: A nationwide French ecologic study

Abstract : Meeting: 20th International Congress Abstract Number: 467 Objective: Using ultraviolet B (UV-B) as a surrogate for vitamin D levels, we conducted a nationwide ecologic study in France in order to examine the association of UV-B exposure with Parkinson's disease (PD) incidence. Background: In addition to regulating calcium homeostasis and bone metabolism, vitamin D is involved in multiple biological pathways. Lower vitamin D is associated with increased mortality, in particular from cancer, and there is increasing evidence that it may play a role in brain health, including Alzheimer's disease, cognitive decline, multiple sclerosis, and PD. Exposure of the skin to UV-B from sunlight is the most important source of vitamin D, and a good surrogate marker of vitamin D levels in population settings. Methods: We used French national drug claims databases to identify PD cases using a validated algorithm. UV-B data from the solar radiation database were derived from satellite images. We estimated PD incidence (2010-2012) at the canton level (small administrative French unit) and used multilevel Poisson regression including a random intercept per canton to examine its association with UV-B (2005 annual average), after adjustment for age, sex, deprivation index, smoking, proportion of agricultural land, and vitamin D supplementation. Results: Analyses are based on 69,010 incident PD patients. PD incidence increased with age and was higher in men than women. The association between UV-B and PD incidence was quadratic (P<0.001) and modified by age (P<0.001) but not by sex (P>0.15). Below 70 years, incidence was higher in the bottom quintile (RR-Q1-45-49y=1.209, 95% CI= 1.108-1.320) compared with the middle UV-B quintile, and lower in the top quintile (RR-Q5-45-49y=0.883 [0.802-0.972]). The opposite pattern was observed in older subjects (RR-Q1-85-89y=0.941 [0.903-0.981]; RR-Q5-85-89y=1.102 [1.057-1.150]). Analyses based on continuous UV-B yielded similar conclusions. Conclusions: In this nationwide ecologic study, there was an age-dependent quadratic association between UV-B and PD incidence. This study suggests that low UV-B exposure is associated with higher PD risk in younger persons, but not in older persons, and that future studies should examine dose-response relations and take age into account.
Liste complète des métadonnées

Littérature citée [1 références]  Voir  Masquer  Télécharger

https://hal-mines-paristech.archives-ouvertes.fr/hal-01335551
Contributeur : Lucien Wald <>
Soumis le : mercredi 22 juin 2016 - 09:40:23
Dernière modification le : vendredi 15 février 2019 - 13:48:34
Document(s) archivé(s) le : vendredi 23 septembre 2016 - 12:06:59

Fichier

www_mdsabstracts_org_abstract_...
Accord explicite pour ce dépôt

Identifiants

  • HAL Id : hal-01335551, version 1

Collections

Citation

A Elbaz, K Sofiane, Lucien Wald, A Dugravot, A Singh-Manoux, et al.. Association of UV radiation with Parkinson's disease incidence: A nationwide French ecologic study. 20th International Congress of Parkinson's Disease and Movement Disorders, International Parkinson and Movement Disorder Society (MDS), Jun 2016, Berlin, Germany. pp.467. ⟨hal-01335551⟩

Partager

Métriques

Consultations de la notice

257

Téléchargements de fichiers

135