Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Abstract : Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.
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https://hal-mines-paristech.archives-ouvertes.fr/hal-01354077
Contributeur : Magalie Prudon <>
Soumis le : mercredi 17 août 2016 - 11:05:52
Dernière modification le : lundi 12 novembre 2018 - 11:05:44

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Diana Ciolacu, Cyrielle Rudaz, Mihai Vasilescu, Tatiana Budtova. Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release. Carbohydrate Polymers, Elsevier, 2016, 151, pp.392-400. ⟨10.1016/j.carbpol.2016.05.084⟩. ⟨hal-01354077⟩

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