In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants

David Moreau; Arthur Villain; Manon Bachy; Henry Proudhon; David N. Ku; Didier Hannouche; Hervé Petite; Laurent Corté

doi:10.1007/s10856-017-5923-6

In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants

David Moreau ^{1, 2} Arthur Villain ^{1, 3} Manon Bachy ³ Henry Proudhon ¹ David N. Ku ⁴ Didier Hannouche ³ Hervé Petite ³ Laurent Corté ^{1, 2}

1 MAT - Centre des Matériaux

2 MMC - Laboratoire Matière Molle et Chimie

3 B2OA UMR 7052 - Bioingénierie et Bioimagerie Ostéo-articulaires ; Biomécanique et Biomatériaux Ostéo-Articulaires

4 George W. Woodruff School of Mechanical Engineering

Abstract : Recently, it has been shown that constructs of poly(vinyl alcohol) (PVA) hydrogel fibers reproduce closely the tensile behavior of ligaments. However, the biological response to these systems has not been explored yet. Here, we report the first in vivo evaluation of these implants and focus on the integration in bone, using a rabbit model of bone tunnel healing. Implants consisted in bundles of PVA hydrogel fibers embedded in a PVA hydrogel matrix. Half of the samples were coated with a composite coating of hydroxyapatite (HA) particles embedded in PVA hydrogel. The biological integration was evaluated at 6 weeks using histology and micro-CT imaging. For all implants, a good biological tolerance and growth of new bone tissue are reported. All the implants were surrounded by a fibrous layer comparable to what was previously observed for poly(ethylene terephthalate) (PET) fibers currently used in humans for ligament reconstruction. An image analysis method is proposed to quantify the thickness of this fibrous capsule. Implants coated with HA were not significantly osteoconductive, which can be attributed to the slow dissolution of the selected hydroxyapatite. Overall, these results confirm the relevance of PVA hydrogel fibers for ligament reconstruction and adjustments are proposed to enhance its osseointegration.

Type de document :

Article dans une revue

Domaine :

Physique [physics] / Matière Condensée [cond-mat] / Science des matériaux [cond-mat.mtrl-sci]

Liste complète des métadonnées

https://hal-mines-paristech.archives-ouvertes.fr/hal-01599772
Contributeur : Bibliothèque Umr7633 <>
Soumis le : lundi 2 octobre 2017 - 15:00:36
Dernière modification le : jeudi 7 février 2019 - 17:07:54

In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants

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In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants

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