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Article Dans Une Revue Science Advances Année : 2019

Targeting CCR5 trafficking to inhibit HIV-1 infection

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Floriane Herit
  • Fonction : Auteur
Isabelle Staropoli
Anne Brelot
Florence Niedergang

Résumé

Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors CCR1 and CXCR4. These molecules are also potent in primary macrophages as they markedly decrease HIV entry. At the molecular level, two of these molecules inhibit the critical palmitoylation of CCR5 and thereby block CCR5 in the early secretory pathway. Our results open a clear therapeutics avenue based on trafficking control and demonstrate that preventing HIV infection can be performed at the level of its receptor delivery.
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Dates et versions

hal-02341238 , version 1 (31-10-2019)

Identifiants

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Gaelle Boncompain, Floriane Herit, Sarah Tessier, Aurianne Lescure, Elaine Del Nery, et al.. Targeting CCR5 trafficking to inhibit HIV-1 infection. Science Advances , 2019, 5 (10), pp.821 - 837. ⟨10.1126/sciadv.aax0821⟩. ⟨hal-02341238⟩
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