Control of a microfluidic separation process governed by the Zweifach-Fung effect

Nicolas Petit (1)

1 CAS - Centre Automatique et Systèmes

This paper presents a microfluidic process of separation of a fluid containing particles. The control input is the ratio of flowrates in the two daughter channels of a bifurcation, which due to the Zweifach-Fung effect, has a direct but nonlinear effect on the particle volume fractions in the channels. The dead-volumes of the device and its capillary tubings cause an input-varying delay of hydraulic type. The paper presents several control problems of practical importance and formulates some concise problem statements for future research along with first simulation results.

Mots clés: Microfluidics device integration technologies process control applications control of micro-and nano-systems control of particulate processes delay systems non-smooth and discontinuous optimal control problems; Microfluidics; device integration technologies; process control applications; control of micro-and nano-systems; control of particulate processes; delay systems; non-smooth and discontinuous optimal control problems

Domaines: Optimisation et contrôle [math.OC]

Nicolas Petit. Control of a microfluidic separation process governed by the Zweifach-Fung effect. 13th IFAC Symposium on Dynamics and Control of Process Systems, including Biosystems 2022, Jun 2022, Busan, South Korea. ⟨hal-04098449⟩