T cells in the pathogenesis of axial spondyloarthritis

Nicolas Rosine (1) , Olivier Fogel (2, 3) , Surya Koturan (4, 5) , Lars Rogge (6) , Elisabetta Bianchi (6) , Corinne Miceli-Richard (2, 3)

1 Service de rhumatologie
2 Service de rhumatologie [CHU Cochin]
3 EULAR - EULAR Center of Excellence, [The European Alliance of Associations for Rheumatology]
4 LMC - MRC London Institute of Medical Sciences
5 Imperial College London
6 Immunorégulation - Immunoregulation

Axial spondyloarthritis (axSpA) is the prototype of the spondyloarthritis spectrum. The involvement of T cells in its pathogenesis has long been suspected on the basis of the association with the major histocompatibility complex I molecule HLA-B27 and the pivotal role of interleukin 17 in the inflammatory mechanisms associated with the disease. Moreover, the presence of unconventional or "innate-like" T cells within the axial enthesis suggests an important role for these cells in the pathophysiology of the disease. In this review, we describe the characteristics and the interleukin 17 secretion capacity of the T-cell subsets identified in axSpA. We discuss the genetic and epigenetic mechanisms that support the alteration of T-cell functions and promote their activation in axSpA. We also discuss recent data on T cells that could explain the extra-articular manifestations of the SpA spectrum.

Mots clés: Axial Spondyloarthritis; IL-17A; SNP; T cells; Tissue resident memory T cells.

Domaines: Immunologie

Nicolas Rosine, Olivier Fogel, Surya Koturan, Lars Rogge, Elisabetta Bianchi, et al.. T cells in the pathogenesis of axial spondyloarthritis. Joint Bone Spine, 2023, 90 (6), pp.105619. ⟨10.1016/j.jbspin.2023.105619⟩. ⟨pasteur-04554930⟩